Domain Access and different locale settings ... is it possible ?

No practical experience, though it was discussed in Barcelona.

The module as written should support separating translated content -- you just post English to the .en site and French to the .fr site. You could even write a little submodule to force users to check a box indicating which language was selected and then assign the domain using that data.

What it likely does not allow is the ability to load different interface translations based on the active domain.

The module structure, however, would support such a feature -- and it seems like a good feature. If you're interested in developing it, take a look at the Domain Configuration module (domain_conf) in the download.

So, in the i10n and i18n areas, what features would you like to have?

I think this is very possible. Anyone willing to work on it?

I believe this is now supported by hook_domainconf() and a small external module.

has anyone managed to make it work or mostly work?