Drupal 6.1 with MySQL 5.5

Hi,

We are currently running Drupal 6.1 with MySQl 5.1. I need to upgrade the MySQL to 5.5 for security reasons. However, I will leave Drupal at version 6.1. Will this combination work?

Also, what should I be aware of when doing a database upgrade like this? Besides backup the DBs, etc..Do I need to update the Drupal config, etc?

Thanks.

Tom