I am migrating a very basic D5 site to a complex D6 site (e.g. from using Pages/Stories to multiple CCK types and rich taxonomy).
I am using pathauto to generate nice names for nodes, which creates a 301 redirect.
Due to the migration, I am changing most of the URLs, using the Path Redirect module, which is gong to mean yet another 301.

Is it possible that these multiple 301s (for most of my about 250 pages) will affect my position in the SERPs?