diff --git a/apc.module b/apc.module
index 31c5f2c..a7e2248 100644
--- a/apc.module
+++ b/apc.module
@@ -1,4 +1,44 @@
 <?php
+/**
+ * Implements hook_xmlrpc().
+ */
+function apc_xmlrpc() {
+  $methods[] = array(
+    'apc_drush_flush',
+    'apc_drush_flush',
+    array(
+      'array',
+      'array',
+    ),
+    t('XMLRPC callback to enable cache clear from Drush/CLI.'),
+  );
+
+  return $methods;
+}
+
+/**
+ * XMLRPC callback to enable cache clear from Drush/CLI.
+ */
+function apc_drush_flush($variables) {
+
+  $cron_key = isset($variables['cron_key']) ? $variables['cron_key'] : NULL;
+
+  if (empty($cron_key) || variable_get('cron_key', 'drupal') != $cron_key) {
+    watchdog('apc', 'APC could not flush cache(s) because an invalid key was used.', array(), WATCHDOG_ERROR);
+    return array(
+      'success' => FALSE,
+      'message' => t('APC could not flush cache(s) because an invalid key was used.'),
+    );
+  }
+  else {
+    // Being invoked from drush. Clear out *all* caches.
+    apc_clear_cache('user');
+    return array(
+      'success' => TRUE,
+      'message' => t('APC user object cache flushed'),
+    );
+  }
+}
 
 /**
  * Implementation of hook_init().
@@ -35,6 +75,16 @@ function apc_permission() {
 }
 
 /**
+ * Implements of hook_exit().
+ */
+function apc_exit() {
+  // Clear drush variable for the next request.
+  global $conf;
+  unset($conf['apc_drush_flushed']);
+
+}
+
+/**
  * See apc_init() which registers this function as a shutdown function.
  * Displays apc stats in the footer.
  */
diff --git a/drupal_apc_cache.inc b/drupal_apc_cache.inc
index 2099c55..9e6e96b 100644
--- a/drupal_apc_cache.inc
+++ b/drupal_apc_cache.inc
@@ -37,6 +37,12 @@ class DrupalAPCCache implements DrupalCacheInterface {
   protected $prefix;
 
   /**
+   * @var boolean
+   */
+  protected $drush_environment;
+
+
+  /**
    * Get prefix for bin using the configuration.
    *
    * @param string $bin
@@ -74,6 +80,7 @@ class DrupalAPCCache implements DrupalCacheInterface {
 
   function __construct($bin) {
     $this->bin = $bin;
+    $this->drush_environment = function_exists('drush_main');
 
     // First we determine the prefix from a setting.
     $prefix = self::getPrefixSettingForBin($this->bin);
@@ -255,8 +262,42 @@ class DrupalAPCCache implements DrupalCacheInterface {
   }
 
   function clear($cid = NULL, $wildcard = FALSE) {
-    if (drupal_is_cli() && function_exists('drush_log')) {
-      drush_log($this->bin . '(' . $cid . ') was not cleared. APC cli uses a different memory storage than the webserver. For more info see: http://drupal.org/node/1278232', 'warning');
+    global $conf;
+
+    // If this is a drush command, we need to wipe the whole cache.
+    // Otherwise we end up with multitudes of xmlrpc requests.
+    // Note that this means blowing away the entire cache on a production
+    // Site if you are using drush.
+    if ($this->drush_environment && !isset($conf['apc_drush_flushed'])) {
+
+      // APC uses separate storage for CLI mode, bounce the clear request back
+      // into this method on all server nodes via XMLRPC.
+      $apc_nodes = variable_get('apc_nodes', NULL);
+      if (!empty($apc_nodes)) {
+        foreach ($apc_nodes as $apc_node) {
+          $args = array(
+            'apc_drush_flush' => array(
+              array(
+                'cron_key' => variable_get('cron_key', 'drupal'),
+              ),
+            ),
+          );
+          $uri = $apc_node . '/xmlrpc.php';
+          $response = xmlrpc($uri, $args);
+
+          if ($response === FALSE) {
+            drush_log('xmlrpc() error: (' . xmlrpc_errno() . ') ' . xmlrpc_error_msg(), 'error');
+          }
+          elseif (!$response['success']) {
+            drush_log('APC could not flush cache(s) because ' . $apc_node . ' returned code ' . $response['message'], 'error');
+          }
+          else {
+            $conf['apc_drush_flushed'] = TRUE;
+            // Skip logging
+            // drush_log($response['message'], 'success');
+          }
+        }
+      }
       return;
     }