diff -u b/core/core.services.yml b/core/core.services.yml
--- b/core/core.services.yml
+++ b/core/core.services.yml
@@ -79,6 +79,7 @@
     class: Drupal\Core\Config\ConfigFactory
     tags:
       - { name: persist }
+      - { name: event_subscriber }
     arguments: ['@config.storage', '@event_dispatcher', '@config.typed']
   config.storage.staging:
     class: Drupal\Core\Config\FileStorage
diff -u b/core/lib/Drupal/Core/Config/ConfigFactory.php b/core/lib/Drupal/Core/Config/ConfigFactory.php
--- b/core/lib/Drupal/Core/Config/ConfigFactory.php
+++ b/core/lib/Drupal/Core/Config/ConfigFactory.php
@@ -9,6 +9,7 @@
 
 use Drupal\Core\Language\Language;
 use Symfony\Component\EventDispatcher\EventDispatcher;
+use Symfony\Component\EventDispatcher\EventSubscriberInterface;
 
 /**
  * Defines the configuration object factory.
@@ -23,7 +24,7 @@
  *
  * @see \Drupal\Core\Config\StorageInterface
  */
-class ConfigFactory {
+class ConfigFactory implements EventSubscriberInterface {
 
   /**
    * Prefix for all language configuration files.
@@ -150,7 +151,7 @@
           if (isset($module_overrides[$name])) {
             $this->cache[$cache_key]->setModuleOverride($module_overrides[$name]);
           }
-          // Apply any settigns.php overrides.
+          // Apply any settings.php overrides.
           if (isset($conf[$name])) {
             $this->cache[$cache_key]->setSettingsOverride($conf[$name]);
           }
@@ -380,7 +381,7 @@
    * It will be the same name with a prefix depending on language code:
    * language.config.LANGCODE.NAME
    *
-   * @param string $names
+   * @param array $names
    *   A list of configuration object names.
    *
    * @return array
@@ -437,2 +438,26 @@
 
+  /**
+   * Removes stale static cache entries when configuration is saved.
+   *
+   * @param ConfigEvent $event
+   *   The configuration event.
+   */
+  public function onConfigSave(ConfigEvent $event) {
+    // Clear out any other cache keys apart from the config object being saved.
+    $saved_config = $event->getConfig();
+    foreach ($this->getCacheKeys($saved_config->getName()) as $cache_key) {
+      if ($this->cache[$cache_key] != $saved_config) {
+        unset($this->cache[$cache_key]);
+      }
+    }
+  }
+
+  /**
+   * {@inheritdoc}
+   */
+  static function getSubscribedEvents() {
+    $events['config.save'][] = array('onConfigSave', 255);
+    return $events;
+  }
+
 }