Migrating from WAMP 2.0i (32 bit) to WAMP 2.2D (64-bit)... Does it Create any Issue for my websites?

I'm Migrating from WAMP 2.0i (32 bit) to WAMP 2.2D (64-bit)...
Does it Create any Issue for my websites?

I'm useing Windows Server 2008 R2.