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Just thought I'd post a link to my article on doing a Multi-Site setup on OS X 10.4. It doesn't require installing MAMP or XAMPP, but you will have to have PHP and MySQL running, which are covered in Manually install MySQL and PHP. Other than that, it's all tools that are included in OS X natively.

I've used some of what can be found here and in other section of the documentation, and tried to bring it all together. Plus I included a cronall script that you can download to automatically cron all your Drupal sites. See the post at http://blogs.martiangraphix.com/2009/09/building-a-drupal-development-en...

Maybe this will help someone.

Michael
Martian Graphix, Inc

Run a linux server inside Parallels or VMware Fusion and connect via ssh, ftp, or mount the htdocs directory via NFS Manager.

Advantages are being able to closely replicate a production environment, avoid modifying your system, and run multiple instances. Disadvantages include the cost of software, virtual machine overhead, and having to install linux.

It is also possible to set this up for Mac OSX Lion/10.7 without MAMP. Apache2 and PHP were already there straight from the Apple factory - installing MySQL was pretty straight forward.

I've written up my own personal experience of installing local multi-site drupal instance(s) and gone on to describe how I sorted out using drush to sync the live and dev sites. I hope it helps someone out there. Please let me know if this would be a useful page edit...

http://workingmatt.blogspot.co.uk/search/label/Drupal