I use the empty cache button. The nodes are refreshed, but for example changes to blocks not. Example: Block was disabled, but is still showing up. Restarting the complete apache (and thus apc) resolves the problem.

Comments

What I have noticed, is that if you are using multiple domains for one site - you need to login and clear the cache for each of the domains.
Is there some way to clear the apc cache for all the domains with one click?
For some of the sites I have 6 and more domains - it becomes quite time consuming just to clear all caches.

nope that is not the problem I'm suffering from. It just doesn't seem to clear the cache of everything properly :s

Status:Active» Postponed (maintainer needs more info)

Can you give me more information about your setup?