The Panels module is an essential tool in the box of every site builder. Panels enables you to make custom layouts quickly and easily with a drag-and-drop interface. Panels is highly extensible and can leverage content, users and taxonomy.

Drupalize.Me offers a series of free videos that explain how Panels can rock your site.

Chapter 1.) Introduction to Panels

Chapter 2.) Creating Multicolumn Pages with Panels

Chapter 3.) Adjusting the Settings for Each Panel Pane

Chapter 4.) Creating Different Versions of the Same Page with Panels

Chapter 5.) Duplicating Variants by Cloning

Chapter 6.) Templates for Content

Chapter 7.) Making Custom Panels Layouts