Run the install script
To run the install script point your browser to the base URL of your website.
The base URL is defined in your Web server configuration file and is specific to the document root where you placed your Drupal files. If you have installed Drupal on a Web server this will likely be a domain name such as http://example.com. If you have installed Drupal on your desktop machine this URL might be http://localhost.

You will be guided through several screens to set up the database, create tables,

add the first user account and provide basic web site settings.

Note
If your site is not configured for clean url's you can troubleshoot this later. The Update notifications box will check for later versions of Drupal and contributed modules. If you are without or have restricted Internet connectivity you may want to uncheck this for now and test and enable it later.
On success, you will see the Drupal installation complete screen. If there are any error message, review and correct them now.
The install script will attempt to create a files storage directory in the default location at sites/default/files (the location of the files directory may be changed after Drupal is installed). In some cases, you may need to create the directory and modify its permissions manually. Use the following commands (from the installation directory) to create the files directory and grant the web server write privileges to it:
mkdir sites/default/files
chmod o+w sites/default/files
The install script will attempt to write-protect the sites/default directory after creating the settings.php file. If you make manual changes to that file later, be sure to protect it again after making your modifications. Failure to remove write permissions to that file is a security risk. Although the default location for the settings.php file is at sites/default/settings.php, it may be in another location if you use the multi-site setup, as explained below.

Fedora Users
You will need to put selinux in permissive mode to do have the permissions work from a web browser.
Even if you have the permissions set correctly for settings.php the install script will think you don't if selinux is
active.
There is probably a way to permit this in selinux but selinux is such a a slow program to bring up and administer
I usually shut it off, as do most other people.
Also bear in mind that permissions must be set to allow writing to the default folder as well so the startup script can create the files folder inside it.
/Len
WT6G
why do I get this?
[an error occurred while processing this directive] The server encountered an internal error and was unable to complete your request. Either the server is overloaded or there was an error in a CGI script. [an error occurred while processing this directive]
I've set up a MySQL database on the server using PHPadmin.
Is it a problem that I loaded the drupal files into their own directory on the root? That is the url for the install is: Http://www.bostonlyme.org/drupal/install.php
My experience installing drupal 6.12 on xampp and windows ...
See http://drupal.org/getting-started/6/install/create-database#comment-1702138