Consider path alisases

Using the "Page specifica Lightbox2 setting" I typed something like "fun/*" but Lightbox2 didn't recognize my page "fun/some-jokes". My further investigations reveal that in $_GET['q'] Drupal passed "node/20932".

Using drupal_get_path_alias() you can retrieve the alias (if exists). Using that edit you can match aliased/unaliased paths for exclude/include lightbox2 JS loading.