Apparently, a preset was malfunctioning and when failing, deleted the original images it was manipulating. Flushing the preset and/or saving it again (without making any settings changes) seemed to get the preset working right again.
See detailed system info and problem description in flickrsync queue, as the issue was originally misidentified as an issue with flickrsync:
http://drupal.org/node/357711#comment-1231086
Comments
Comment #1
xolotl commentedActually, the issue may indeed be due to flickrsync updating via cron.
See new note in flickrsync queue:
http://drupal.org/node/357711#comment-1232236
Comment #2
xolotl commentedProvisionally: Issue seems to be with flickrsync, not imagecache, see above.
Comment #3
fizk commented