This modules provides a new Panels Renderer Pipeline.
It's actually a more of a "router pipeline".. It will check against an array of regions to be "IPE Enabled". All other regions will render as normal and won't be editable through IPE.
The array of "IPE Enabled" regions can be overriden with a database variable.
This is a quick-fix before this is/might be integrated into panels itself. Here's the issue for that #1821618: Ability to lock regions from IPE completely