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I did two things that were significantly different from the multi-site instructions. So far they are working on my local installation, but have not yet been tested in online sites.
This was done in Drupal 7 running under XAMPP 5.6.3.
The Drupal Remote Dashboard (DRD) is a module for system administrators to monitor and manage any number of Drupal installations at once and it's built to be extensible by other modules.
For example, DRD enables you to place all your monitored sites into Maintenance mode, Clear the cache, run Cron or update.php.
The Multisite Manager contributed module allows creation of new Drupal sites from a central Drupal site without the creator having access to database info. The new site is installed either in the same database with a different prefix or if the drupal db_user has access to create a database and grant privileges, then possibly there.
Get started by reading the INSTALL.txt documentation.